Biosecurity, Policy and Science

July 4, 2006

Government Against RAS

Filed under: Biotechnology,Uncategorized — rabodzey @ 8:07 pm

www.russ.ru/docs/121825952
My new article “Government Against RAS” came out in Russian Journal (in Russian).
It discusses the benefits and drawbacks of the proposed reform of Russian scientific institutions.
Major idea of the reform is to cut the number of scientific institutions funded by the Government and increase governmental funding to the remeining ones. Russian approach towards scientific institutions was to try to keep scarce funding for all RAS (Russian Academy of Sciences) institutions instead of trying to fund only those who achive best results. This reform is a late recognition of the fact.

In spite of the benefits of the reform, it is not clear how selection criteria will be determined and what will happen to the institutions left without funding.

June 29, 2006

Filed under: Russian Biosecurity — rabodzey @ 4:35 pm

http://www.vector.nsc.ru/DesktopDefault.aspx?lcid=25
Today a head of Russian State Research Center of Virology and Biotechnology (VECTOR) L.S. Sandakhchiev died.
He was well-known to Biosecurity community in and outside Russia.
VECTOR is the leading Russian scientific institution dealing with pathogens and development of vaccines.

June 22, 2006

PIR Center Nonproliferation Summer School

Filed under: Russian Biosecurity — rabodzey @ 1:37 pm

http://pircenter.org/index.php?id=1248&news=2159

‘The PIR Center Nonproliferation Summer School provides its participants with a unique opportunity of personal interaction with leading nonproliferation experts – those who shaped nonproliferation and nuclear security policy in the past and influence it today’, – Nonproliferation Summer School-2005 graduate, IAEA Department of Safeguards expert Nadezhda Logutova.

June 15, 2006

Pandemic Influenza: Science and Policy.

Filed under: Biosecurity — rabodzey @ 5:47 pm

Pandemic Influenza: Science and Policy.
MIT Workshop June 15th .

Session 1: Policies for Pandemic Influenza

1. Opening by Sanford Weiner.

Swine flu case, 40mln people immunization, 25 people died as a result of vaccine. UK came to a conclusion that no program on immunization should be started instead of what US did. 1976 CDC position was to declare emergency and make vaccine and implement it. Too many assumptions come unexamined.

HA is the one that the body makes most antibodies against, then NA. 16 HA and 9 NA discovered so far. RNA virus mutates a lot more than DNA. 3 HA in humans, many others in other species (birds). In birds it is often intestinal and benign. The mechanism of spread of the disease is not well understood.

Sometimes flu jumps to other species: seals, horses etc. 2003 H7 killed one human and infected many. H5N1 is notable for that too. Hong Kong 1997 in farm chickens, after 6 human dies they killed millions of poultry.

H5N1 went from 25 to 50 countries this winter, but in most cases in wild birds (ducks etc). Few chicken farms were infected in EU. Dozen countries with human deaths: Vietnam and Thailand. Vietnam handled it to zero. Now a number of deaths is in Indonesia.

In the last 100 years jump from animals never happened to cause epidemics. 1957, 1968 – major flu pandemics. History of flu is not enough to draw reasonable conclusions about periodicity.

Mortality of H5N1 is about 50%, but it is partly an artifact of the data collection. Thus 50% may not be accurate. Recent dead rate in Vietnam ~35% down from 70% in early years. It is not clear what would be the rate if human transmission develops.

Worst case analysis of human pandemics. After Katrina everybody has to consider the worst-case scenario. Pandemic flu 1918 is the case we always consider.

June 6, 2006

MIT SSP Conducts Workshop on Influenza

Filed under: Biosecurity — rabodzey @ 6:33 pm

It seems that security community shifted its interest from Smallpox and Anthrax towards
less deadly but easier to obtain pathogens. MIT SSP Program conducts a workshop on
influenza on 15th of June. The group of speakers is diverse, surprisingly only one person:
Peter Palese is actually influenza specialist. However Jens Kuhn is certainly another person who
is well aware of epidemiology and biology of infectious diseases.

MIT Workshop on Pandemic Influenza: Science and Policy
June 15, 2006, Killian Hall (Building 14)
Presented by the Security Studies Program, Center for International Studies, MIT, and co-sponsored by Center for Technology and National Security Policy, National Defense University.
http://web.mit.edu/ssp/news/index.html

Session 1: Policies for Pandemic Influenza
1:00pm -3:00 pm
Speakers:
Laura Kelly, Public Health Associate, National Intelligence Council, Central Intelligence Agency
Sanford L. Weiner, Research Associate, MIT Security Studies Program
Discussant:
Barrett D. Slenning, Professor, Animal Biosecurity Risk Management Group, North Carolina State University

Session 2: The Science of Pandemic Influenza
3:30pm-5:30 pm
Speaker:
Peter Palese, Professor and Chair, Department of Microbiology, Mount Sinai Medical Center, New York
Discussants:
Stephen C. Schoenbaum, Executive Vice President, The Commonwealth Fund, and Harvard Medical School
Jens Kuhn, Research Scholar, New England Primate Research Center, Harvard Medical School

This event is open to the public.

June 5, 2006

Global Security and G8 Conference in Moscow April 20-22 2006

Filed under: Russian Biosecurity — rabodzey @ 5:01 am

Biological security became a major security issue in the US since 2001. At the same time Russia, although one of the major political powers in the modern world, has not recognised threat of biological terrorism for a while. Biological terrorism was perceived as a part of terrorism and handled by anti-terrorist agencies as such.

Moscow PIR Center http://www.pircenter.org/ and its head Mr. Orlov made biosecurity one of their priorities and conducted conferences on BW threat. PIR Center’s journal Nuclear Non-proliferation (published in Russian and English) also published a number of articles on biosecurity and bioterrorism prevention (including mine in YADERNY KONTROL 2005 1-2 in English and 2005 3 in Russian).

During the recent Global Security Conference in Moscow, a special section on biosecurity :”Biological Security: Counteracting Infectious Diseases through International Cooperation” (СЕКЦИОННОЕ ЗАСЕДАНИЕ 2
Биологическая безопасность: противодействие инфекционным заболеваниям через международное сотрудничество) has been conducted. Questions addressed during the conference showed increased interest of Russian policymakers and polictical scientists in the topic.

Materials of this and other sections may be found on the website: http://pircenter.org/index.php?id=222 or http://pircenter.org/index.php?id=1256&news=541&pglang=rus&pg=page_doc in Russian.

Comments on the article at the Technology Review on biosecurity

Filed under: Biosecurity — rabodzey @ 12:32 am

Technology Review (April-May 2006) published my comments to the lead article for March issue:
“The Knowledge” http://www.technologyreview.com/read_article.aspx?id=16485
by Mr. Mark Williams. It appears that Mr. Williams is a staff reporter of the journal
who took interview from Mr. Sergei Popov from George Mason University
National Center for Biodefense and Infectious Diseases http://ncbid.gmu.edu/
headed by Mr. Ken Alibek.

The original article may be found here http://www.technologyreview.com/read_article.aspx?id=16485
My comments posted by the journal:
Williams writes that even if we enacted George Church’s proposal to register all DNA synthesizers and force certain classes of researchers to work transparently, “not all nations would comply. For instance, Russian biologists, some of whom are known to have worked at Biopreparat, have reportedly trained molecular-biology students at the Pasteur Institute in Tehran.” It is important to note that educating students in molecular biology is by no means a violation of the Biological Weapons Convention (BWC) by itself. Moreover, even though the Soviet Union violated the BWC by developing bioweapons on its own territory, there has never been any known transfer of pathogens or weapons technology to third parties. Thus we have no reason to claim that Russia is a suspect country. Today, Russia is an active member of the BWC, and it renounced any bioweapons development activities in 1992. The problem of noncompliance is a very important one and is a major obstacle in the way of international implementation of the control mechanisms, but most experts would agree that this threat is not coming from Russia.
Aleksandr Rabodzey
Cambridge, MA
http://www.technologyreview.com/read_article.aspx?id=16780&ch=infotech

Editor of the journal considered the second part of my letter “not interesting” and it was omitted
from the journal. I still believe it may be a valid comment and publish it here:

Hello dear editor of the Technology Review, I am writing to you regarding the article “The Knowledge” by Mr. Mark Williams published in the last March’s issue. I want to emphasize the importance of bringing into the discussion the topic of biological weapons threat assessment, it is important that MIT community is getting involved into this talk more and more. The issues of control over biotechnology were brought up in the recent Student Pugwash discussions and by members of MIT Security Studies Program and Science, Technology, and Global Security Working Group at MIT.
The article presents very balanced opinion on the problem of biological weapons development. One may notice that as we look at the works in the area of BW threat assessment, reasonable scientific approach overcomes initial hysteria and fear of BW. It is very important that we, as members of MIT scientific community keep to these highest standards and present accurate and scientifically supported conclusions. It is also important that we cover the whole variety of options and solutions proposed to resolve the problem of controls over biotechnology.
That is why I think it is important to add few comments to Mr. Williams’s article. Thus, in the last chapter of his discussion “Is help on the way?” Mr. Williams claims that “…no one has a good idea about what should be done”. Mr. Williams quotes one of the possible solutions proposed by Prof. Church of Harvard, while misses to present other policy propositions such as those by Stanford’s CISAC Christopher Chyba and Alex Greninger in their paper “Biotechnology and Bioterrorism: An Unprecedented World” Survival (2004), by Center for International and Security Studies at Maryland (CISSM), University of Maryland, John Steinbruner and Stacy Okutani “The Protective Oversight of Biotechnology”, Biosecurity and Bioterrorism, Dec 2004, Vol. 2, No. 4: 273-280, by Sandia Laboratory’s Reynolds Salerno and Jennifer Gaudioso “Science and government. Biosecurity and research: minimizing adverse impacts”, Science. 2004 Apr 30; 304(5671): 687, “Biotechnology Research in an Age of Terrorism” by National Research Council, 2004, “Biosecurity implications of the synthesis of pathogenic viruses” Politics and the Life Sciences, September 2003 vol. 22, no. 2 and more.
Thus one cannot say that no one has a good idea about what should be done, instead, there is a discussion about the traded-offs of biotechnology controls. The discussion is very vivid and a number of propositions have already been implemented. Moreover, some steps have already been made by biotech industry itself, like it was proposed in papers cited above: Blue Heron Technologies – one of the biotech companies providing custom sequences synthesis currently compares all of the ordered sequences against pathogen genomes database. There is a long way ahead of us and we have to work further on implementation of the controls.

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